The Forum HIV Prevention Project is guided by a Steering Committee. The Steering Committee provides overall guidance, leadership, and expertise to the Project and its working groups. The Steering Committee includes representation from regulatory and other governmental agencies, multilateral and other international organizations, funders, academia, industry, community, and civil society. The Steering Committee is led by two co-chairs and the principal investigator of the Project. The current Steering Committee members are listed below (* denotes Steering Committee co-chairs). The Forum is responsible for convening the Steering Committee quarterly and communicating with the Steering Committee any important developments in the Project.
| Industry / industry experience | |
| Jared Baeten | Gilead Sciences |
| Christian Ramers | Gilead Sciences |
| Vani Vannappagari | ViiV Healthcare |
| Scott McCallister | ViiV Healthcare |
| Rafael Campo | Merck |
| Michael Robertson | Independent consultant |
| Academia / research / healthcare provider | |
| Beatriz Grinsztejn | FIOCRUZ |
| Deborah Donnell | Fred Hutchinson Cancer Research Center |
| Jean-Michel Molina | French National Agency for AIDS Research |
| Sheena McCormack | University College London |
| Kenneth Mayer* | Fenway Health |
| Dave Glidden | UCSF |
| Sinead Delany-Moretlwe | Wits RHI |
| Connie Celum | University of Washington |
| Helen Rees* | Wits RHI |
| Nyaradzo Mgodi | HIV Prevention Clinical Trials Network |
| Ethics | |
| Jeremy Sugarman | Johns Hopkins University |
| Jerome Singh | University of Toronto / University of KZN |
| Advocacy, civil society, community | |
| Mitchell Warren | AVAC |
| Grace Kumwenda | AVAC |
| Ntando Yola | Desmond Tutu Health Foundation |
| Daniel Driffen | HVTN |
| Funding organizations / donors | |
| Max Lataillade | Gates Foundation |
| Sheryl Zwerski | DAIDS, NIAID/NIH |
| National regulatory agencies / regulatory expertise | |
| Kim Struble | US Food & Drug Administration (FDA) |
| Maja Sommerfelt Gronvold | European Medicines Agency (EMA) |
| Kedibone Malatji | South African Health Products Regulatory Authority (SAHPRA) |
| Jeffrey Murray | Independent consultant |
| International and multilateral organizations | |
| Michelle Rodolph | World Health Organization |
| Jude Nwokike | United States Pharmacopeia |
| Farisai Kuonza | Africa CDC |