The Forum HIV Prevention Project is guided by a Steering Committee. The Steering Committee provides overall guidance, leadership, and expertise to the Project and its working groups. The Steering Committee includes representation from regulatory and other governmental agencies, multilateral and other international organizations, funders, academia, industry, community, and civil society. The Steering Committee is led by two co-chairs and the principal investigator of the Project. The current Steering Committee members are listed below (* denotes Steering Committee co-chairs). The Forum is responsible for convening the Steering Committee quarterly and communicating with the Steering Committee any important developments in the Project.
| Members | Affiliations |
| Academic | |
| Connie Celum | University of Washington |
| Sinead Delany-Moretlwe | Wits RHI |
| Deborah Donnell | Fred Hutchinson Cancer Research Center |
| Dave Glidden | UCSF |
| Beatriz Grinsztejn | FIOCRUZ |
| Kenneth Mayer* | Fenway Health |
| Sheena McCormack | University College London |
| Nyaradzo Mgodi | HIV Prevention Clinical Trials Network |
| Jean-Michel Molina | French National Agency for AIDS Research |
| Helen Rees* | Wits RHI |
| Ethics | |
| Jerome Singh | University of Toronto / University of KZN |
| Jeremy Sugarman | Johns Hopkins University |
| Funding Organizations | |
| Max Lataillade | Gates Foundation |
| Sheryl Zwerski | DAIDS, NIAID/NIH |
| Industry | |
| Jared Baeten | Gilead Sciences |
| Rafael Campo | Merck |
| Scott McCallister | ViiV Healthcare |
| Christian Ramers | Gilead Sciences |
| Michael Robertson | Independent consultant |
| Vani Vannappagari | ViiV Healthcare |
| International Organizations | |
| Farisai Kuonza | Africa CDC |
| Jude Nwokike | United States Pharmacopeia |
| Michelle Rodolph | World Health Organization |
| Professional Societies & Organizations | |
| Daniel Driffen | HVTN |
| Grace Kumwenda | AVAC |
| Mitchell Warren | AVAC |
| Ntando Yola | Desmond Tutu Health Foundation |
| Regulatory | |
| Maja Sommerfelt Gronvold | European Medicines Agency (EMA) |
| Kedibone Malatji | South African Health Products Regulatory Authority (SAHPRA) |
| Jeffrey Murray | Independent consultant |
| Kim Struble | US Food & Drug Administration (FDA) |